Posters Archives | Quantum-Si

Combining deep mutational scanning and Next-Generation Protein Sequencing to harness dominant protein variants to develop DNA repair inhibitors

AACR 2026 Poster – The most clinically effective DNA repair enzyme inhibitors convert the protein target itself into a therapeutic agent. Topoisomerase poisons block the completion of the topoisomerase reaction resulting in a genotoxic DNA-protein adduct. Similar mechanisms underlie clinically relevant PARP inhibitors and other emerging therapeutics targeting DNA Damage Response proteins. Which repair proteins […]

High-resolution detection of post-translational modifications using single-molecule protein sequencing

AGBT 2026 Poster – Post-translational modifications (PTMs) play a critical role in regulating protein function and cellular processes. However, due to the diversity and complexity of the proteome, methods to detect and quantify PTMs have lagged behind advances in DNA sequencing. While conventional mass spectrometry and antibody-based methods provide valuable information, they are limited in […]

Identification and characterization of protein complexes using a benchtop single-molecule protein sequencer

US HUPO 2026 Poster – Accurate and efficient protein identification remains a central challenge in modern biochemistry and molecular biology. Traditional methods often depend on antibody-based detection, which can be limited by antibody availability and specificity, or on complex and costly instrumentation that restricts accessibility for many laboratories. Consequently, there is a growing need for […]

High-throughput in vivo screening of extra-hepatic lipid nanoparticles enabled by machine learning design of novel chemistry

ESGCT 2024 Poster – The promise of nucleic acid-based therapeutics is immense for treating a wide range of diseases. The challenge lies in the ability to deliver these therapies to their intended sites in body, ideally specifically and efficiently. Lipid nanoparticles (LNPs) have emerged as a powerful tool for delivery due to their ability to encapsulate […]

Reducing Protein Input for Next-Generation Protein Sequencing on the Platinum® Instrument

US HUPO 2025 Poster – next-generation protein sequencing (NGPS) on the Quantum-Si Platinum® and Platinum® Pro instruments enable the direct analysis of individual proteins at an unprecedented resolution.1 However, one challenge in applying this technology to biological and clinical samples is the limited availability of input protein. Quantum-Si’s Library Preparation Kit, V1 recommends a protein […]

Protein Barcoding and Next-Generation Protein Sequencing for Multiplexed Protein Selection, Analysis, and Tracking

US HUPO 2025 Poster – Protein barcoding has emerged as a powerful tool for the multiplexed identification and characterization of proteins, providing a mechanism for precise tracking of protein affinity, location, and expression. In this study, we describe the development of a protein barcoding workflow for use with single-molecule next-generation protein sequencing (NGPS) on the […]

Accurate Measurement of Peptide Variant Mixtures with Next-Gen Protein Sequencing (NGPS)

US HUPO 2025 Poster – ProteoVue™ is a comprehensive bioinformatics pipeline for single-amino acid variant (SAAV) detection and quantification using the Quantum-Si Platinum® and Platinum® Pro NGPS instruments. ProteoVue integrates pulse calling, recognition segment detection, fluorescence dye classification, and a neural network-driven kinetic signature database to enable variant calling with high sensitivity and specificity. These […]

Next-Generation Protein Sequencing Resolves Peptide Variants Derived from Tropomyosin Proteoforms

US HUPO 2025 Poster – next-generation protein sequencing (NGPS) resolves proteotypic representing the three main types of regulation — genetic, splicing, and post-translational modifications — contributing to proteomic molecular diversity. Kinetic signatures produced by NGPS are a novel orthogonal datatype that can complement other commonly used proteomics approaches. NGPS data can be used for a range of […]

Beyond the Genome: Advancing our Understanding of the Proteome with Next-Gen Protein Sequencing

Protein information is a crucial component of multiomics workflows, offering insights that integrate genetic, transcriptomic, and proteomic data for a more comprehensive understanding of biological systems. Multiomics studies would greatly benefit from methods that enable direct protein detection and characterization with exceptional sensitivity. In this context, we present the unique capabilities of next-generation protein sequencing […]

Quantum-Si’s Next-Gen Protein Sequencer Enables Protein Detection and Peptide Characterization from Biological Samples

Studies of the proteome would greatly benefit from methods that enable direct protein detection and peptide characterization with exceptional sensitivity. In this context, we present the unique capabilities of next-gen protein sequencing on Quantum-Si’s Platinum® instrument, which utilizes single-molecule protein sequencing to achieve detection of unknown proteins and protein variants. Individual peptides are digested from […]