ASMS 2026 Poster – Identification of hemoglobin (Hb) variants is of significant value in the clinical diagnosis of hemoglobinopathies. Conventional methods used to identify Hb variants in clinical laboratories can narrow down the range of candidates for a Hb variant sample but are unable to pinpoint the exact Hb variant. In this study, a semiconductor […]
ASMS 2026 Poster – Post-translational modifications (PTMs) are critical regulators of protein function and are extremely diverse in both types and frequencies1 While many PTMs can be readily identified, identification and site localization can still be challenging when the PTM introduces small mass changes or when multiple modification sites are possible Here, we demonstrate how N-terminal amino acid (NAA) recognizer-based sequencing, an emerging single-molecule […]
PEGS Boston 2026 Poster – Accurate and efficient protein identification remains a central challenge in modern biochemistry and molecular biology. Traditional methods often depend on antibody-based detection, which can be limited by antibody availability and specificity, or on complex and costly instrumentation that restricts accessibility for many laboratories. Consequently, there is a growing need for […]
AACR 2026 Poster – The most clinically effective DNA repair enzyme inhibitors convert the protein target itself into a therapeutic agent. Topoisomerase poisons block the completion of the topoisomerase reaction resulting in a genotoxic DNA-protein adduct. Similar mechanisms underlie clinically relevant PARP inhibitors and other emerging therapeutics targeting DNA Damage Response proteins. Which repair proteins […]
AGBT 2026 Poster – Post-translational modifications (PTMs) play a critical role in regulating protein function and cellular processes. However, due to the diversity and complexity of the proteome, methods to detect and quantify PTMs have lagged behind advances in DNA sequencing. While conventional mass spectrometry and antibody-based methods provide valuable information, they are limited in […]
US HUPO 2026 Poster – Accurate and efficient protein identification remains a central challenge in modern biochemistry and molecular biology. Traditional methods often depend on antibody-based detection, which can be limited by antibody availability and specificity, or on complex and costly instrumentation that restricts accessibility for many laboratories. Consequently, there is a growing need for […]
ESGCT 2024 Poster – The promise of nucleic acid-based therapeutics is immense for treating a wide range of diseases. The challenge lies in the ability to deliver these therapies to their intended sites in body, ideally specifically and efficiently. Lipid nanoparticles (LNPs) have emerged as a powerful tool for delivery due to their ability to encapsulate […]
US HUPO 2025 Poster – next-generation protein sequencing (NGPS) on the Quantum-Si Platinum® and Platinum® Pro instruments enable the direct analysis of individual proteins at an unprecedented resolution.1 However, one challenge in applying this technology to biological and clinical samples is the limited availability of input protein. Quantum-Si’s Library Preparation Kit, V1 recommends a protein […]
US HUPO 2025 Poster – Protein barcoding has emerged as a powerful tool for the multiplexed identification and characterization of proteins, providing a mechanism for precise tracking of protein affinity, location, and expression. In this study, we describe the development of a protein barcoding workflow for use with single-molecule next-generation protein sequencing (NGPS) on the […]
US HUPO 2025 Poster – ProteoVue™ is a comprehensive bioinformatics pipeline for single-amino acid variant (SAAV) detection and quantification using the Quantum-Si Platinum® and Platinum® Pro NGPS instruments. ProteoVue integrates pulse calling, recognition segment detection, fluorescence dye classification, and a neural network-driven kinetic signature database to enable variant calling with high sensitivity and specificity. These […]