Discover Protein Variants with Unmatched Precision on Platinum™
Dive into the intricacies of protein variations using the state-of-the-art Platinum sequencing platform.
Why Choose
Platinum?
Utilizing single-molecule sequencing combined with fluid workflow integration, Quantum-Si’s Platinum streamlines protein variant detection and advances proteomic research in your laboratory.
Convenient
Seamlessly incorporate protein identification into your current research process using the compact Platinum next-generation protein sequencer™, complemented by our collaborative Cloud software.
Accessible
Now any lab can efficiently pinpoint proteins using an intuitive process that autonomously produces amino acid determinations, streamlining data analysis and facilitating effortless exploration.
Insight-generating
Benefit from protein sequencing that offers unparalleled sensitivity, achieving single-molecule and individual amino acid precision. This allows for protein identification without the need for affinity reagents, paving the way for impartial discoveries.
The detection of pathological variants in ß-amyloid proteins, especially those related to the amyloid precursor protein mutation, is pivotal for monitoring the progression of Alzheimer’s disease. While traditional methods often miss these subtle yet crucial mutations, Quantum-Si’s next-generation protein sequencing™ technology offers a revolutionary approach. It not only detects early signs of Alzheimer’s through amino acid mutations in ß-amyloid proteins but also detects the amyloid precursor protein mutation with precision. This advancement paves the way toward a deeper understanding of the disease’s progression and the potential for refining treatment strategies.
In this application note, we show how Quantum-Si’s single-molecule protein sequencing platform can effectively detect individual amino acid alterations linked to the progression and severity of Alzheimer’s.
Figure 1 demonstrates the structural alterations in ß-amyloid proteins that lead to the formation of pathological plaques, a hallmark of Alzheimer’s disease. The figure provides a detailed view of how these proteins undergo changes, exposing hydrophobic regions that induce aggregation and subsequent plaque formation. This data contributes to a molecular-level understanding of Alzheimer’s pathogenesis.
Here we demonstrate the pulse patterns observed in one ß-amyloid mutation, contrasting it with the patterns of the wild type. This figure offers visual data on how single point mutations impact the sequencing process and, consequently, our understanding of Alzheimer’s disease. Download the application note to compare more mutations and understand the capability of advanced sequencing technology in differentiating between normal and pathological variants.
This application note showcases Quantum-Si’s protein sequencing technology on the Platinum instrument, which enables the rapid and accurate distinction of variants of the SARS-CoV-2 virus based on differences in the amino acid sequence of their Spike proteins. By identifying and tracking these variants, scientists can better understand their impact on public health and develop effective treatments and vaccines.
Download the application note to learn more about this groundbreaking technology.
Focusing on a key mutation, we observed the distinctive kinetic influences on recognizer binding. The clear differences in pulse durations (PD) between the peptides of interest highlight the power of Quantum-Si’s Platinum instrument in differentiating the Alpha variant from the Delta and Omicron variants through a single mutation.
Here we highlight the differentiation of the Omicron variant from the Alpha and Delta variants based on the detection of a single peptide. The capability to identify variant-specific peptides contributes to the accurate and precise distinction of SARS-CoV-2 variants using Quantum-Si’s Platinum instrument.
Featured Resources
POSTER
Single-Molecule Protein Sequencing on the Quantum-Si Platform: Advances in Protein and Proteoform Identification and Comparison With Mass Spectrometry
WHITE PAPER
Digitizing Protein Sequencing: Detecting Individual Amino Acids through Real-Time Photon Emission
PEER-REVIEWED ARTICLE