Next-Generation Protein Sequencing™ Made Scalable, Accessible, and Insightful

Next-generation DNA sequencing greatly advanced our understanding of biology and genes’ influence on biological function. Next-Generation Protein Sequencing answers critical questions about what is happening in the body now.

  • Is a specific protein there or not?
  • Which proteins are important?
  • Why are they important?
  • How do proteins change in disease?

With Platinum®, you can answer these critical questions quickly, right in your own lab.

Learn About Our Technology

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How It Works

Prepare

Library Preparation and Sequencing Kits contain everything you need,
including reagents to digest and functionalize proteins and immobilize peptides on semiconductor chips, along with aminopeptidases and
recognizers to commence the sequencing process.

Sequence

Platinum sequences individual peptides by capturing the fluorescent signal from each N-terminal amino acid (NAA) binding event. Aminopeptidases cleave each N-terminal amino acid, exposing the next N-terminal amino acid for recognition, and the process repeats until the whole peptide is sequenced.

Analyze

Data generated during each run is automatically uploaded to the Platinum Analysis Software. Our analysis software delivers single molecule level information about your proteins making protein identification easy to interpret without the need for bioinformatics expertise.

Expand the Frontiers of Proteomics With Platinum

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Platinum Differs from Mass Spectrometry

Platinum is designed to fit the space, budget, and existing expertise of most labs interested in generating insights from protein sequencing data. Our technology identifies proteins using unique Kinetic Signatures based on the binding kinetics of amino acid recognition events. In contrast, mass spectrometry infers protein identification based on the mass:charge ratio which may not distinguish protein variants of similar size.

The Platinum Next-Generation Protein Sequencing workflow is easy to implement and delivers answers quickly – no need for extensive infrastructure or bioinformatics expertise, as required by mass spec.

Compare Platinum to Mass Spec

Platinum Differs from Immunoassays

Next-Generation Protein Sequencing provides deeper insights with single-molecule resolution that, unlike immunoassays, enables assessment of what is actually happening at the amino acid level.

  • Verify the specificity of your antibodies by sequencing the target protein.
  • Sequence the protein band from your gel.
  • Uncover what is there, not just what could be there.
  • Interrogate protein variants not resolved by antibodies.

Sequence Proteins from Gels

Platinum Differs from Edman Degradation

Platinum Next-Generation Protein Sequencing leverages a one-pot reaction without complex and expensive cyclical chemistry and fluidics to achieve single amino acid resolution. With Platinum technology, you benefit from:

  • Deeper protein sequencing discoveries.
  • Easy protein sequencing workflows.
  • Affordable protein sequencing solutions.

Kinetic Signatures

Accelerating the Path to Discovery

A Kinetic Signature comprises the measurable characteristics of the series of dynamic recognizer events that uniquely identifies a peptide. Kinetic Signatures change dynamically with alterations in amino acid and post-translational modifications (PTMs), providing a reliable means to accurately align peptides to their respective proteins. Unlike other technologies, Kinetic Signatures offer a robust and confident approach to this alignment.

As Next-Generation Protein Sequencing becomes more widespread, Kinetic Signatures will be crucial to identifying every amino acid and every PTM, making Quantum-Si’s technology key to advancing our understanding of the proteome.

See Platinum in Action!

Request A Demo

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