Join an exclusive gathering of leaders in protein science for a first look at Proteus™ — a next-gen platform designed to redefine protein analysis. We will be covering, breakthrough application data, case studies from leading research institutions and a forward-looking roadmap for the Proteus platform.
This is not a product presentation, but a strategic dialogue with select innovators, shaping the future of protein research.
Space is limited and brunch/lunch will be served, so register today to save your seat.
We hope you will join us to explore — and help define — what comes next. Keep reading
AGBT 2026 Poster – Post-translational… Keep reading
US HUPO 2026 Poster –… Keep reading
Proteins play a vital role in virtually all biological processes, serving as key regulators of cellular functions, disease biomarkers, and therapeutic targets. However, the identification, isolation, and characterization of proteins from biological specimens can be challenging due to their complexity and diversity. Next-Generation Protein Sequencing (NGPS) on Platinum® offers a groundbreaking approach to deeply interrogate individual proteins with high resolution on a user-friendly benchtop platform. When combined with protein separation or enrichment methods, Platinum enables characterization of individual proteins from biological samples, revealing crucial details such as amino acid variants and PTMs. In this application note, we demonstrate a method that combines Sodium dodecyl-sulfate polyacrylamide gel electrophoresis (SDS-PAGE) protein separation and NGPS on Platinum to identify and characterize serum proteins. This method holds potential for applications beyond serum, offering new insights into disease mechanisms and advancing therapeutic and diagnostic developments. Keep reading
Identification of hemoglobin (Hb) variants is of significant value in the clinical diagnosis of hemoglobinopathies. Conventional methods used to identify Hb variants in clinical laboratories can narrow down the range of candidates for a Hb variant sample but are unable to pinpoint the exact Hb variant. In this study, next-generation protein sequencing (NGPS), a semiconductor chip-based single-molecule protein sequencing (SMPS) technology, was explored as a novel method to identify Hb variants. Two heterozygous Hb variant samples underwent NGPS analysis. Proteotypic peptides corresponding to Hb variants were successfully detected, enabling the identification of the samples as Hb Handsworth (Hb α-Handsworth subunit G18R) and Hb G-Accra (Hb β-G-Accra subunit D73N). The NGPS method has been demonstrated as a potential tool to identify Hb variants. Although there are still limitations to overcome for the wide adoption of NGPS, this exploration supports the potential use of NGPS and other SMPS technologies in clinical applications. Keep reading
Proteins are a class of macromolecules with essential roles in processes and structures associated with life. Protein sequencing technologies are therefore fundamental for understanding cell metabolic pathways, disease mechanisms, and how pathogenic agents and toxins function. Emerging next generation protein sequencing (NGPS) technologies promise a dramatic improvement of proteomics methods enabling identification of pathogens and toxins with unparalleled sensitivity and precision. The Quantum-Si (QSi) Platinum Sequencer is a novel single molecule protein sequencing technology capable of single amino acid resolution. In this work, we conducted significant optimization of the QSi protein library preparation protocol, reducing sample preparation time from 32 to 10 hours without sacrificing substantial sequencing quality, allowing for a sample-to-answer timeline in less than 24 hours. The modified protocol was applied for analyzing a set of proteins including sixteen single-domain antibodies with diverse sequences and a nontoxic derivative of staphylococcal enterotoxin B. We were further able to determine the library dilution threshold: losing the ability to sequence beyond 100x dilution. Finally, we were able to successfully obtain protein sequences within a crude lysate background, demonstrating the effectiveness of sequencing within complex protein mixtures. Improvements in sequencing chemistry and data processing may soon lessen or eliminate the dependence on reference sequences: a current obstacle for efficiently characterizing unknown proteins. By further condensing and optimizing library preparation, this technique presents a potential application for proteomics that require rapid characterization of highly complex biological systems, significantly improving protein-based diagnostic technologies. Keep reading
Join us at the 15th Annual Congress of the European Proteomics Association in Würzburg, Germany from 29 November to 3 December. Keep reading
Network with 1,500+ colleagues at the largest protein & antibody engineering event in Europe, which has also been described as "the best biologics technology meeting in Europe." The 2025 event will feature expanded coverage in ML/AI applications in protein engineering, multispecific antibodies, ADCs, emerging targets, oncology, expression, and analytical characterisation. Keep reading
The ASHG 2026 Annual Meeting Is Headed to Montréal! Join QSI at booth 1416 for a week of groundbreaking science, exciting technological advances, global connections, and community. Keep reading
HUPO Congresses continue to grow each year — drawing participants from over 60 countries across academia, industry, and clinical research. HUPO 2026 will be no exception: a global gathering where science meets collaboration, and innovation meets impact.
World HUPO 2026 in Singapore will continue HUPO’s strong tradition of supporting the next generation. Look forward to Early Career Researcher (ECR) sessions, mentorship opportunities, and hands-on workshops designed to build skills, confidence, and connections for the future leaders of proteomics. Keep reading