Next-Generation Protein Sequencing™ on Quantum-Si Platinum™: Advances in Protein Identification


Next-Generation Protein Sequencing™ is a transformational tool for protein science to unlock new insights into the function of proteins in health and diseases. Quantum-Si’s Platinum™ technology brings the insights of protein sequencing to every lab with a space-friendly benchtop instrument, a simple end-to-end workflow, and single-molecule resolution that enables detection of protein variants and modifications.

Herein, we employed Platinum to sequence and identify both single proteins or a mixture of proteins, proteins either enriched or immunoprecipitated from biofluids, as well as protein bands extracted from electrophoresis gels.

Results demonstrate that Platinum can be used to effectively identify protein variants with single-molecule resolution in a simple workflow.