Beyond the Genome: Identification of Protein Sequence and PTMs with Quantum-Si’s Next-Generation Protein Sequencer™ Platinum®


To demonstrate the versatility of Platinum and the use of kinetic signatures, we sequenced various types of samples, including mixtures of recombinant proteins, peptides with post-translational modifications (PTMs), proteins immunoprecipitated from human serum, and proteins isolated from human serum via fractionation with SDS-PAGE. The resulting peptides generated distinct kinetic signatures aligned to their respective sequences, highlighting the efficacy of Quantum-Si’s sequencing platform in analyzing multi protein mixtures at reduced input concentrations.