Aberrant post-translational modifications (PTMs) on arginine residues, namely methylation and citrullination, are closely linked to oncogenic processes. Detection of these PTMs is challenging with current technologies and can be hampered by low abundance and mass differences that are difficult to resolve by mass spectrometry. To overcome these hurdles, we developed methods for PTM detection using […]

Next-gen protein sequencing is a transformational tool for protein science to unlock new insights into the function of proteins in health and disease. Quantum-Si’s Platinum technology brings the insights of protein sequencing to every lab with a space-friendly benchtop instrument, a simple end-to-end workflow, and single-molecule resolution that enables detection of protein variants and modifications […]

Peptide-level analysis coupled with amino acid resolution is important to elucidate how proteins influence health and disease. Peptide-centric methodologies using liquid chromatography-tandem mass spectrometry (LC-MS/MS) are widely used to detect native and modified proteins. While LC-MS/MS stands as the dominant bottom-up proteomics technique, accessing LC-MS/MS and interpreting MS/MS spectra remains challenging. Due to the large […]