SelectScience Webinar 2024

In this webinar, Dr. Michael Caldwell, Scientific Officer at Northwestern Proteomics Center of Excellence, will explore top-down mass spectrometry (TD-MS) and Platinum®. Platinum is a benchtop instrument that provides single amino acid resolution of single protein molecules to characterize IL-6, including pyroglutamate (pE), a post-translational modification (PTM) produced via enzymatic and spontaneous cyclization of N-terminal glutamine (Q)/glutamate (E) residues.

Time: 9 AM PST | 12 PM EST | 5 PM BST

Harness the power of protein sequencing in your lab

Next-gen protein sequencing (NGPS) offers a unique means to investigate proteins at a level of resolution inaccessible with other technologies. Moreover, with advanced single-molecule protein sequencing technologies like Quantum-Si’s Platinum® Pro instrument, researchers can now reliably identify changes to proteins at the amino acid level. Download our latest eBook and explore how NGPS can advance […]

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Single-molecule sequencing of immunopeptides and antigenic protein markers on the Platinum® instrument

Summary:  Single-molecule protein sequencing offers the sensitivity needed to explore the immunopeptidome and profile tumor-associated antigens. We demonstrate the use of the Platinum benchtop instrument to sequence immunopeptides and proteins at the single-molecule level. Peptides are loaded into nanoscale chambers on a chip, where dye-labeled N-terminal amino acid recognizers bind and generate distinct kinetic patterns. […]

Accelerate Protein Screening by Sequencing Protein Barcodes on Platinum®

Screening protein variants of interest is an essential step when studying mechanism of disease or developing novel biotherapeutics. Current screening methods require either back-to-back design-build-test cycles or large arrayed screens using automation, which can lead to lengthy assay timelines, technical challenges, unwanted variability and unnecessary cost. Furthermore, traditional phage-display or yeast-display methods may not be […]