Detecting Scarce Isoform-Specific Peptides Using Next-Generation Protein Sequencing™

“The proteome is chemically and functionally complex and multidimensional, and the analytical techniques used to characterize it, such as mass spectrometry, can only get us so far. There is a ceiling. What attracted us to Next-Generation Protein Sequencing™ is the single molecule detection technology. This allows us to detect proteoforms with subtle amino acid variations – small changes that can have big implications for protein function.”

Explore the case study to understand how researchers are using Platinum^® as a powerful and complementary technology to mass spectrometry to investigate how proteoform variation underlies human disease.