Case Study

Detecting Scarce Isoform-Specific Peptides Using Next-Generation Protein Sequencing™

Gloria Sheynkman, PhD
Assistant Professor, Department of Molecular Physiology and Biological Physics
University of Virginia School of Medicine

“The proteome is chemically and functionally complex and multidimensional, and the analytical techniques used to characterize it, such as mass spectrometry, can only get us so far. There is a ceiling. What attracted us to Next-Generation Protein Sequencing™ is the single molecule detection technology. This allows us to detect proteoforms with subtle amino acid variations – small changes that can have big implications for protein function.”

Explore the case study to understand how researchers are using Platinum® as a powerful and complementary technology to mass spectrometry to investigate how proteoform variation underlies human disease.