Real-Time Dynamic Single-Molecule Protein Sequencing on an Integrated Semiconductor Device


Single-molecule protein sequencing is a transformational tool for protein science that will unlock new insights into the function of proteins in health and disease. Direct sequencing of single protein molecules offers the maximum possible detection sensitivity, with the potential to enable single-cell inputs, digital quantification based on read counts, detection of posttranslational modifications (PTMs) and low-abundance or aberrant proteoforms, and cost and throughput levels that favor broad adoption.

Quantum-Si developed the Platinum™ platform that has a small footprint and low cost with the aim of making protein sequencing accessible to the average research lab.

Initial applications focus on purified or enriched protein samples and include comparing relative abundance of proteins or proteoforms, affinity reagent validation, discovery of PTMs, and digital barcoding based on peptide sequences.