Resource Category: Poster

Summary: Single-molecule protein sequencing is a transformational tool for protein science that will unlock new insights into the function of proteins in health and disease. Direct sequencing of single protein molecules offers the maximum possible detection sensitivity, with the potential to enable single-cell inputs, digital quantification based on read counts, detection of posttranslational modifications (PTMs) and […]

Summary: Aberrant post-translational modifications (PTMs) on arginine residues, namely methylation and citrullination, are closely linked to oncogenic processes. Detection of these PTMs is challenging with current technologies and can be hampered by low abundance and mass differences that are difficult to resolve by mass spectrometry. To overcome these hurdles, we developed methods for PTM detection […]