Resource Category: App Notes
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Enrichment and Sequencing of Albumin Protein from Urine
Summary: Disease-related diagnosis often requires enrichment of protein markers from biofluids. Analyzing biomarkers and variants of biomarkers, such as albumin, from biofluids is important to understand disease. Urine represents an ideal biomarker source as samples can be collected via non-invasive methods, enabling temporal monitoring of patient conditions. In addition, physiological states are often reflected in […]
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Sequencing and Identification of Proteins from Five-protein Mixtures on Platinum™
Summary: Complex biological samples consist of multiple proteins. Understanding the presence and relative abundance of different proteins in a sample can provide important information about the biological processes underlying human health and disease. Some protein detection techniques identify proteins using antibodies or other affinity-based reagents with specificity for the proteins of interest. These methods require […]
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Comparison of Protein Sequencing Analysis of CDNF on Platinum™ and Mass Spectrometry
Summary: Mass Spectrometry has been the gold standard for deciphering information about a protein’s amino acid sequence. However, mass spectrometry is not convenient and accessible to everyday scientists with its large capital equipment expense and advanced expertise requirement. Scientists often need to resort to using core facilities to sequence proteins. Furthermore, mass spectrometry infers amino […]
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Quantum-Si’s Next Generation Protein Sequencing Technology Enables Rapid and Accurate Distinction of Variants of the SARS-CoV-2 Virus
Summary: Accurate and rapid identification of SARS-CoV-2 variants is crucial for effective surveillance and disease monitoring. Furthermore, patients with long COVID may still have residual spike protein in their blood. Distinguishing variants in long COVID patients via protein sequencing could lead to new understandings and treatment of the disease. In this application note, we present a […]
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Protein Identification via Next-Generation Protein Sequencing and Proteome-Wide Mapping
Summary:Proteins are the main structural and functional components of biological cells. Assembled and structured through the complexfolding of a specific sequence of amino acids, proteins, along with their dynamic regulation and post-translational modifications (PTMs), largely determine cellular phenotype. New tools to study these changes are necessary. Quantum-Si’s technology uses a proprietary, novel sequencing approach– […]
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Detecting Arginine Post-Translational Modifications Using Quantum-Si’s Next-Generation Protein Sequencing Technology
Summary:Proteins are the main structural and functional components of biological cells. Assembled and structured through the complexfolding of a specific sequence of amino acids, proteins, along with their dynamic regulation and post-translational modifications (PTMs), largely determine cellular phenotype. New tools to study these changes are necessary. Quantum-Si’s technology uses a proprietary, novel sequencing approach– […]
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Monitoring Alzheimer’s Progression by Detecting Pathological Variants in ß-amyloid Protein
Summary:Proteins are the main structural and functional components of biological cells. Assembled and structured through the complexfolding of a specific sequence of amino acids, proteins, along with their dynamic regulation and post-translational modifications (PTMs), largely determine cellular phenotype. New tools to study these changes are necessary. Quantum-Si’s technology uses a proprietary, novel sequencing approach– […]