Senior Scientist, Chemical Biology and Biophysics

Guilford, Connecticut

Company Description

Quantum-Si is pioneering a new generation of technology to create the market of Next Generation Protein Sequencing (NGPS). Similar to Next Generation DNA Sequencing (NGS), which gave us a blueprint of what could happen by studying our DNA, NGPS enables an unbiased view of the proteome through improved scale, resolution, and sensitivity leading to better understanding of disease and improved general health. 

We operate at the intersection of biochemistry, chemistry, hardware, molecular biology, photonics, semiconductor chips, and software with a goal to drive a digital transformation of a $44 billion dollar proteomics market.

Join us on the journey to transform healthcare, motivated by the idea that the products you work on will change the lives of millions of people around the world.

Job Description

The R&D team at Quantum-Si is responsible for bringing our technology to life. For more than a decade, next-generation DNA sequencing has transformed every aspect of the life sciences. However, genetics is only one component of human disease. New tools are required to understand how genes interact with the environment to improve how we develop drugs, diagnose patients, and combat outbreaks. The R&D team plays a critical role in developing products that will be used all around the world. Come work alongside a world-class team of scientists and engineers to define a new frontier for next generation sequencing.

As Sr. Scientist, Chemical biology and Biophysics, you are an expert in the design and implementation of high-throughput kinetic and binding assays. You have direct experience working with aptamers and using them in the creation of novel applications. You have a deep love for working in a fast-paced pre-commercial startup environment and are self-motivated.

As part of our team, your core responsibilities will be: 

  • Work closely with external collaborators to develop and leverage high-throughput processes for evolving new DNA/RNA (aptamers) against small molecule and protein targets
  • Develop high-throughput kinetics and binding-based assays to screen aptamers developed by external collaborators
  • Apply modern bio-conjugation techniques to site-selectively label macromolecules. 
  • Leverage aptamers to design and execute single molecule experiments involving complex kinetic and bioconjugation requirements
  • Work with a multidisciplinary team in support of cross-company research, development, and manufacturing activities


Baseline skills/experiences/attributes:

  • Ph.D. degree in Chemistry, Biochemistry, Biophysics, or related field. 2+ years of post-doctoral/relevant industry experience is preferred, but not required.
  • Direct experience with SELEX or other in vitro molecular evolution techniques for aptamer development
  • Knowledge and understanding of modern bio-conjugation techniques and experience modifying biomolecules such as nucleic acids and polypeptides
  • Experience with macromolecular purification methods like HPLC, LCMS, SEC, CD, gel-shift assays is required. 
  • Proficiency in fluorescence and interferometry-based assay is preferred, but not required. 

You Deeply Identify with Core Quantum-Si Values:

  • Efficient & Speedy - you get work done in a fraction of the time as industry peers 
  • Intellectually Curious - you are thoughtful & inquisitive; people enjoy working with you because they learn from you
  • Mission-Driven & Committed - you are passionate about the company's purpose and are immensely productive
  • Team Oriented - you celebrate and take joy in the success of others on the team

Additional Information

We offer great perks: 

  • Fully covered medical insurance plan, and dental & vision coverage - as a health-tech company, we place great worth on our teams’ well-being
  • Competitive salaried compensation - we value our employees and show it 
  • Equity - we want every employee to be a stakeholder
  • Pre-tax commuter benefits - we make your commute more reasonable 
  • Free onsite meals + kitchen stocked with snacks.
  • 401k plan - we facilitate your retirement goals
  • Beautiful office near the ocean-front in historic Guilford, Connecticut 
  • The opportunity to build a revolutionary healthcare product and save millions of lives! 

For this role, we provide visa assistance for qualified candidates. 

Quantum-Si does not accept agency resumes.

Quantum-Si is an E-Verify and equal opportunity employer regardless of race, color, ancestry, religion, gender, national origin, sexual orientation, age, citizenship, marital status, disability or Veteran status. All your information will be kept confidential according to EEO guidelines.