Research Scientist, Protein Engineering

Frederick, Maryland

Company Description

Quantum-Si is pioneering a new generation of technology to create the market of Next Generation Protein Sequencing (NGPS). Similar to Next Generation DNA Sequencing (NGS), which gave us a blueprint of what could happen by studying our DNA, NGPS enables an unbiased view of the proteome through improved scale, resolution, and sensitivity leading to better understanding of disease and improved general health. 

We operate at the intersection of biochemistry, chemistry, hardware, molecular biology, photonics, semiconductor chips, and software with a goal to drive a digital transformation of a $44 billion dollar proteomics market.

Join us on the journey to transform healthcare, motivated by the idea that the products you work on will change the lives of millions of people around the world.

Job Description

The R&D team at Quantum-Si is responsible for bringing our technology to life. For more than a decade, next-generation DNA sequencing has transformed every aspect of the life sciences. However, genetics is only one component of human disease. New tools are required to understand how genes interact with the environment to improve how we develop drugs, diagnose patients, and combat outbreaks. The R&D team plays a critical role in developing products that will be used all around the world. Come work alongside a world-class team of scientists and engineers to define a new frontier for next generation sequencing.

As a Research Scientist, Protein Engineering you will leverage directed evolution techniques to create new binding proteins compatible with our single molecule detection platform. You have a deep love for working in a fast-paced pre-commercial startup environment and are self-motivated. 

As part of our team, your core responsibilities will be: 

  • Design and prepare DNA libraries for high throughput selection
  • Perform selections, prepare and submit samples for NGS, and analyze sequencing results
  • Work closely with team members to validate novel binding proteins, as well as develop new methods for protein engineering


Baseline skills/experiences/attributes:

  • MS with 3+ years of industry experience in Molecular Biology, Biochemistry, Biomolecular Engineering, or related field
  • Team player and accountable to deliverables
  • Excellent organizational, analytical, communication, and presentation skills
  • Skilled in advanced molecular biology techniques for variant library generation
  • Familiarity with cell culture of E. coli, S. cerevisiae, and/or M13 phage.
  • Familiarity with directed evolution and display technologies such as yeast, phage, ribosome, or SNAP display.
  • Experience in analysis of next generation DNA sequencing datasets

You Deeply Identify with Core Quantum-Si Values:

  • Efficient & Speedy - you get work done in a fraction of the time as industry peers 
  • Intellectually Curious - you are thoughtful & inquisitive; people enjoy working with you because they learn from you
  • Mission-Driven & Committed - you are passionate about the company's purpose and are immensely productive
  • Team Oriented - you celebrate and take joy in the success of others on the team


Additional Information

We offer great perks: 

  • Fully covered medical insurance plan, and dental & vision coverage - as a health-tech company, we place great worth on our teams’ well-being
  • Competitive salaried compensation - we value our employees and show it 
  • Equity - we want every employee to be a stakeholder
  • Pre-tax commuter benefits - we make your commute more reasonable 
  • Free onsite meals + kitchen stocked with snacks.
  • 401k plan - we facilitate your retirement goals
  • Beautiful office in Frederick, Maryland
  • The opportunity to build a revolutionary healthcare product and save millions of lives! 

For this role, we provide visa assistance for qualified candidates. 

Quantum-Si does not accept agency resumes.

Quantum-Si is an E-Verify and equal opportunity employer regardless of race, color, ancestry, religion, gender, national origin, sexual orientation, age, citizenship, marital status, disability or Veteran status. All your information will be kept confidential according to EEO guidelines.